Effects of chronic cannabis and tobacco use on vascular endothelial function 

(CANnabis: Does It Damage Endothelium?)

Study overview

Research Topic: Effects of chronic cannabis and tobacco use on vascular endothelial function            



detail-iconLocation: UCSF Mission Bay San Francisco, CA




Compensation: In return for your time and effort, you will be paid $100 for taking part in a one 2-hour clinic visit.



Why is the CANDIDE study being done?

We are studying the effects of cannabis and tobacco use and secondhand smoke exposure on vascular function.

There is widespread belief that, unlike tobacco smoke, cannabis smoke is benign. While the psychoactive substance in cannabis is tetrahydrocannabinol (THC) rather than nicotine, cannabis smoke is still the result of burning plant material and contains many of the same thousands of chemicals as tobacco smoke, including fine particles that cause cardiovascular disease and death. However, due to the prior illegality of cannabis, it has been difficult to study the harmful effects of cannabis smoke, and the few secondhand smoke (SHS) studies have focused primarily on whether people exposed to SHS risk testing positive on drug tests. The increasing number of states legalizing medicinal and recreational cannabis make it important to understand the public health consequences of both active and secondhand exposure to cannabis smoke.


As a CANDIDE participant, you will

  • ​Complete a brief survey 
  • Participate in a phone interview to assess your eligibility for this study
  • Attend a one 2-hour visit and complete various study procedures such as vitals, non-invasive arm ultrasound, saliva and urine collection, and a blood draw
  • Receive $100 at the end of your visit 
Who Can Participate? 
  • Participants must be 18-50 years old
  • Participants must be able to speak and read English

Exclusion Criteria

  • Physician diagnosis of chronic medical conditions such as asthma, heart disease, hypertension, thyroid disease, dyslipidemia, diabetes, renal or liver impairment, glaucoma
  • Pregnant or breastfeeding 
Types of Users we are Looking to Recruit 
  • Cannabis smokers
  • Cannabis vaporizer users
  • THC edible users 
  • People exposed to secondhand cannabis smoke or cannabis aerosol 
  • Tobacco smokers
  • People exposed to secondhand tobacco smoke 
  • Non-users/Non-smokers